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Magyar, M; Gattringer, T; Enzinger, C; Hassler, E; Partl, R; Khalil, M; Reishofer, G; Deutschmann, H; Fazekas, F.
Incidence of Developmental Venous Anomalies in Patients With Multiple Sclerosis: A 3 Tesla MRI Study.
Front Neurol. 2022; 13: 824347 Doi: 10.3389/fneur.2022.824347 [OPEN ACCESS]
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Leading authors Med Uni Graz: Magyar Marton
Co-authors Med Uni Graz: Deutschmann Hannes; Enzinger Christian; Fazekas Franz; Gattringer Thomas; Hassler Eva Maria; Khalil Michael; Partl Richard; Reishofer Gernot
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Abstract:: Objectives: There is evidence of involvement of the venous system in multiple sclerosis (MS). If this bears also an association with the frequency and extent of developmental venous anomalies (DVA) still has to be determined. We therefore investigated this in patients with different phenotypes of MS and in comparison, to a control population. Methods: We analyzed the contrast-enhanced T1-weighted MR scans of 431 patients (clinically isolated syndrome-CIS, n = 108; MS, n = 323) and of 162 control individuals for the presence of a DVA. We also measured the size of the DVA and draining vein and compared the DVA frequency between MS phenotypes. Results: A DVA was found in 38 (8.8 %) of patients with CIS or MS and in 11 (6.8%) controls (p = 0.4). DVA frequency was highest in CIS (14.8%) and lowest in progressive MS (4.0%). The mean cranio-caudal and axial extension of the DVA was significantly lower in MS patients than controls (p < 0.05). Conclusions: The frequency of DVA in MS patients is comparable to that in controls. Whether DVA size and appearance may change over time will have to be investigated in a longitudinal manner and with larger sample size.
Find related publications in this database (Keywords): multiple sclerosis; developmental venous anomaly (DVA); central nervous system; magnetic resonance imaging; clinically isolated syndrome (CIS)