Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Eisenberger, K.
A Review of Animal Models in Colorectal Cancer Research
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2025. pp.
- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Leber Bettina
- Stiegler Philipp
- Altmetrics:
- Abstract:
- Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide, with complex pathophysiology that complicates therapeutic approaches. Despite advancements in surgical and chemotherapeutic options, challenges such as metastasis, drug resistance, and adverse side effects necessitate innovative therapies. Emerging solutions like siRNA-based interventions demonstrate promise but require rigorous preclinical validation to overcome hurdles in stability and delivery. Animal models play a pivotal role in this process, offering a controlled platform to test new treatments. In this systematic review, we analyzed 26 studies from the past 15 years focused on injection-based carcinogenesis in small animal models. Our aim was to identify standardized practices in animal and cell line selection, injection methods, volumes and cell concentrations. The findings highlight the variability in methodologies, underscoring the need for consistency to streamline future research and enhance translational relevance. Our review concludes that adopting precise and minimally invasive approaches, such as endoscopic injection, in anatomically scalable models like rats, could bridge the gap between experimental designs and human CRC pathology. These insights are intended to guide the development of robust and reproducible CRC animal models for advancing therapeutic innovations.