Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Rajesh, R.
The Role of Succinate in Pulmonary Fibrosis
PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2026. pp.
- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Angiari Stefano
- Bärnthaler Thomas
- Heinemann Akos
- Marsh Leigh
- Altmetrics:
- Abstract:
- Idiopathic pulmonary fibrosis or IPF is a chronic and progressive interstitial lung disease associated with a poor post-diagnosis survival rate of 3-5 years. Characterized by repetitive scarring of lung tissue, loss of alveolar integrity and compromised gas exchange, IPF has limited treatment options with patients ultimately requiring lung transplantation. While current therapeutics slow disease progression and lung function decline, they do not halt or reverse the established disease. Thus, there is a pressing need to identify novel curative therapeutic strategies. Metabolomic studies have revealed that several metabolic pathways including glucose metabolism, amino acid metabolism and lipid metabolism are altered in IPF patients. Importantly, studies from the last decade have also highlighted dysregulation of the tricarboxylic acid (TCA) cycle or the Krebs cycle which is a central hub to several metabolic pathways.