Medizinische Universität Graz - Research portal
Selected Publication:
Schweiger, L.
Relevance of cardiac biomarker in patients with peripheral arterial disease
Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2025. pp.
- Authors Med Uni Graz:
- Advisor:
- Gary Thomas
- Raggam Reinhard Bernd
- Toth-Gayor Gabor
- Altmetrics:
- Abstract:
- Lower extremity artery disease (LEAD) affects over 200 million people worldwide. The advanced stage of this disease is referred to as chronic limb threatening ischemia (CLTI) and is associated with increased morbidity and mortality. This is reflected in a one-year mortality rate of approximately one quarter among CLTI patients, while amputation rates reach about 30% within one year. Despite the significant socioeconomic impact of LEAD, it remains largely underrepresented compared to other cardiovascular research fields. Cardiac biomarkers such as troponin T and N-terminal pro-brain natriuretic peptide (NT-proBNP) are well-studied and firmly established in the cardiology setting. However, their significance in the context of LEAD is largely unexplored. Only a few studies have investigated cardiac biomarkers in LEAD patients, demonstrating an association between LEAD and elevated cardiac biomarker levels. The aim of this study was to assess differences in cardiac biomarkers between the stages of LEAD and to evaluate the predictive value of cardiac biomarkers in patients with LEAD.