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Pammer, A.
Investigating HDL Function and Metabolism in Heart Failure, Liver Cirrhosis and Diabetes Mellitus
PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2025. pp.

Authors Med Uni Graz:
Advisor:: Frank Sasa; Marsche Gunther; Wadsack Christian
Altmetrics:
Abstract:: Beyond traditional assessments of low-density lipoprotein cholesterol (LDL-C), there is an increasing focus on the functional properties of high-density lipoprotein (HDL) as critical modulators in the pathophysiology of lifestyle-driven chronic diseases. Obesity often triggers a series of metabolic disturbances, such as insulin resistance, which can lead to type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease. Whether occurring independently or in combination, these conditions significantly contribute to the development and progression of acute heart failure and liver cirrhosis or failure. HDL has traditionally been evaluated through static measurements of HDL cholesterol (HDL-C). However, growing evidence suggests that HDL functionality, including cholesterol efflux capacity, antioxidant activity, and anti-inflammatory effects, offers a more precise and clinically meaningful reflection of cardiovascular and metabolic risk.