Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Haidegger, M.
Understanding the pathophysiology of cerebral small vessel disease: The Graz Lacunar Stroke Study II (GLAS-II)
Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2025. pp.
- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Eller Kathrin
- Enzinger Christian
- Gattringer Thomas
- Altmetrics:
- Abstract:
- Cerebral small vessel disease (CSVD) is one of the leading causes of ischaemic stroke, cognitive impairment and dementia. The pathophysiology is incompletely understood, therefore specific therapeutic approaches are not available yet. Cerebrovascular reactivity (CVR), increased arterial pulsatility and arterial stiffness are possible mechanisms of CSVD. CSVD causes lacunar ischaemic stroke, depicted as recent small subcortical infarcts (RSSI) on neuroimaging. Little is known about the incidence and aetiology of recurrent cerebrovascular events in RSSI patients. The identification of clinical and imaging risk factors is therefore of substantial clinical importance.