Medizinische Universität Graz - Research portal
Selected Publication:
Hirtl, M.
Targeting mitochondrial Ca²⁺ uptake and investigating spatial MICU1 and MCU distribution dynamics in cells
PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Mediziniche Universität Graz; 2025. pp.
- Authors Med Uni Graz:
- Advisor:
- Graier Wolfgang
- Groschner Klaus
- Malli Roland
- Altmetrics:
- Abstract:
- Mitochondrial Ca²⁺ uptake is a crucial and tightly controlled process in various tissues. Even small changes in the key proteins involved in this process can lead to cellular dysfunction and, ultimately, cell death. In the inner mitochondrial membrane (IMM), the mitochondrial Ca²⁺ uniporter (MCU) forms a multimer with the essential MCU regulator (EMRE), creating a Ca²⁺-permeable pore that is regulated by mitochondrial Ca²⁺ uptake 1 (MICU1). As the pivotal powerhouse of the cell, mitochondria are involved in many pathologies, and the protein complex involved in mitochondrial Ca²⁺ uptake has received a lot of attention as a promising target for pharmacological interventions.