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Ascani, A.
Androgen receptor and immune activation: analysis of the role of B cells as mediators of polycystic ovary syndrome.
PhD-Studium (Doctor of Philosophy); Humanmedizin; [ Dissertation ] Medizinische Universität Graz; 2024. pp. 158 [OPEN ACCESS]
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Authors Med Uni Graz:
Advisor:: Horvath Angela; Moissl-Eichinger Christine; Obermayer-Pietsch Barbara
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Abstract:: Polycystic ovary syndrome (PCOS) has been associated with variations in B cell frequencies although the mechanism remains unclear. This lifelong inflammatory disease is defined by reproductive and metabolic disorder, and previous attempts to identify an autoimmune cause have been relatively uninformative. The aim of this thesis was twofold: to establish, if self-reactive B cells have causal effects, and to investigate the overall impact of high androgen exposure on B cell phenotypes, particularly Double Negative (DN) B memory cells, as well as circulating antibody titres.