Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Safron, R.
Diagnostic value of 68Ga-DOTA-NOC PET/CT in Somatostatin-receptor positive tumours of the gastrointestinal tract: a retrospective study
Humanmedizin; [ Diplomarbeit ] Medizinische Universität Graz; 2021. pp. 44
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- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Nazerani-Zemann Tina
- Stanzel Susanne
- Altmetrics:
- Abstract:
- Abstract Subject: The goal of this retrospective study is the evaluation of the value of 68Ga-DOTA-NOC-PET/CT in diagnosing and staging of histologically verified neuroendocrine tumours (NET) of the gastrointestinal tract (GI). Method: 68Ga-DOTA-NOC-PET/CT images of 31 patients with histologically verified NET of the GI were analysed. Primary tumour sites of the GI-tract and the distant metastases, if present, were quantified via measurement of SUVmax- and SUVmean-values (maximum and mean standardized uptake value, respectively). The SUVmax of these lesions were compared with the WHO-classification(G1, G2, G3) of NET and tumour marker values. In the analysis of SUVmax-values with primary and secondary tumor sites, only patients with G1 and G2 tumours were considered, because only one patient with G3 tumour was present. Results: Via 68Ga-DOTA-NOC-PET/CT, 26 primary tumour sites in the colon ascendens, colon descendens, in proximity to the valvula ileocoecalis, caecum, stomach, duodenum, ileum, and jejunum amidst 31 patients could be detected. The SUVmax did not show significant correlation with G1 and G2 tumours. Significant correlation was present between age of patients and SUVmean. Another significant correlation was found between the tumour localisation and SUVmax-values. Tumour markers did not correlate significantly with SUVmax-values. Conclusion: 68Ga -DOTA-NOC-PET/CT is a suitable tool for staging of NETs of the GI-tract. It allows early detection of tumours in early stages. 68Ga-DOTA-NOC-PET/CT is inferior to histopathological examinations because SUVmax-values do not differ between G1 and G2 lesions.