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Selected Publication:

Pilic, J.
The Role of Eukaryotic Initiation Factors in Psoriasis
[ Diplomarbeit/Master Thesis (FH) ] FH Joanneum; 2020.

 

Authors Med Uni Graz:

Advisor:

Golob-Schwarzl Nicole

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Abstract:

Psoriasis is a chronic inflammatory skin disease affecting over 125 million people worldwide. The role of eukaryotic initiation factors (eIFs) in the pathophysiology of psoriasis is poorly understood. Through regulation of protein synthesis, eIFs affect many cellular processes, which are essential for normal skin function. Dysregulation in protein synthesis and can explain the uncontrolled skin growth observed in psoriasis. We therefore believe that eIFs are involved in pathophysiology of psoriasis and might be promising therapeutic targets. Here we study the pathophysiology of psoriasis in human skin and in imiquimod (IMQ) mouse model. Topical application of IMQ induces psoriasis-like skin inflammation in mice, which closely resemble human psoriasis lesions. We further examine the effect of ultraviolet B (UVB) treatment on eIF expression in IMQ mice, since the exact mechanisms of UVB treatment are not fully understood.

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