Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Trummer, C.
Effects of vitamin D supplementation on endocrine and metabolic parameters in women with and without polycystic ovary syndrome
Doktoratsstudium der Medizinischen Wissenschaft; Humanmedizin; [ Dissertation ] Graz Medical University; 2018. pp. 97
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- Autor*innen der Med Uni Graz:
- Trummer Christian
- Betreuer*innen:
- Klaritsch Philipp
- Lerchbaum Elisabeth
- Obermayer-Pietsch Barbara
- Theiler-Schwetz Verena
- Altmetrics:
- Abstract:
- Introduction: Growing evidence suggests a possible association of vitamin D status with clinical features of polycystic ovary syndrome (PCOS), including insulin resistance, ovulatory dysfunction, and hyperandrogenemia. The aim of this dissertation was to evaluate the effects of vitamin D supplementation on endocrine and metabolic parameters in PCOS. Furthermore, these effects were also assessed in a study group of premenopausal women without PCOS. Material and Methods: In total, 180 PCOS patients and 150 women without PCOS with a 25-hydroxyvitamin D [25(OH)D] serum concentration <75 nmol/L were recruited. Participants were 2:1 randomized to receive 20,000 IU of cholecalciferol or placebo over 24 weeks. Primary study outcome was the difference in plasma glucose area under the curve (AUCgluc) between the vitamin D and the placebo group at study end with adjustment for baseline values. Results: In the PCOS group, 123 participants completed the study, while 127 participants completed the study in the group without PCOS. At baseline, we found significant differences in several parameters between the groups with and without PCOS, including anthropometric measurements, parameters of glucose homeostasis, and serum androgen levels. Vitamin D supplementation had no significant effect on our primary outcome measure (AUCgluc) in both groups. However, vitamin D supplementation lead to a significant decrease in plasma glucose after 60 minutes during oral glucose tolerance test (OGTT) in the PCOS group, while it lead to a significant increase in homeostatic model assessment – insulin resistance (HOMA-IR) and a significant decrease in quantitative insulin sensitivity check index (QUICKI) in the group without PCOS. Conclusions: Vitamin D supplementation had no significant effect on AUCgluc in women with and without PCOS, while it had a significant impact on some of our secondary outcome parameters.