Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Merres, A.
The predictive value of the Neutrophil to lymphocyte ratio, the modified
glasgow prognostic score and the CRP to albumin ratio for patients with
pancreatic cancer after curative resection.
A retrospective single center study
Humanmedizin; [ Diplomarbeit ] Graz Medical University; 2017. pp.
[OPEN ACCESS]
FullText
- Autor*innen der Med Uni Graz:
- Betreuer*innen:
- Kornprat Peter
- Marsoner Katharina
- Altmetrics:
- Abstract:
- Background: Pancreatic cancer is still considered to be one of the deadliest cancers and curative resection is currently the only curative option. Prognostic factors like the neutrophil to lymphocyte ratio (NLR), the modified Glasgow prognostic score (mGPS)and the CRP to Albumin ratio (CRP/Alb ratio) were already found to be probate indicator tools in various cancer types to categorize patients and foresee their progression. This study investigates the prognostic strength of the factors regarding the overall survival of patients with pancreatic cancer who underwent curative pancreatic resection. Methods: A total of 202 patients with adenocarcinoma of the pancreas who underwent total resection at the surgical center of the Medical University Graz were subject to a retrospective review. The overall survival was assessed using the method of Kaplan-Meier. Univariate and multivariate Cox regression analysis were applied to predict the prognostic strength of NLR, mGPS and CRP/Alb ratio. Results: The CRP/Alb ratio is an independent prognostic factor regarding overall survival in univariate and multivariate Cox regression analysis. It is associated with a higher Charlson Index, a higher UICC classification, an increased CEA level and preoperative symptoms (especially preoperative pancreatitis, jaundice and weight loss). NLR and mGPS were associated with a decreased overall survival only in univariate analysis. Additional factors associated with a worse outcome were lymph node involvement, metastasis and a higher UICC classification. Conclusion: The CRP/Alb ratio is a useful prognostic factor for the prediction of overall survival for patients who suffer from pancreatic cancer after pancreatic resection. It also proves to be superior to the other prognostic factors investigated, NLR and mGPS. Based on the potential benefit, individual risk assessment based on the CRP/Alb ratio should be considered in the future.