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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Matzi, V; Lindenmann, J; Porubsky, C; Kugler, SA; Maier, A; Dittrich, P; Smolle-Jüttner, FM; Joukhadar, C.
Extracellular concentrations of fosfomycin in lung tissue of septic patients.
J Antimicrob Chemother. 2010; 65(5): 995-998.
Doi: 10.1093/jac/dkq070
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- Leading authors Med Uni Graz
- Matzi Veronika
- Co-authors Med Uni Graz
- Lindenmann Jörg
- Maier Alfred
- Porubsky Christian
- Smolle-Juettner Freyja-Maria
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- Abstract:
- The present investigation explored the ability of fosfomycin to penetrate lung tissue of septic patients by utilizing the microdialysis technique. After microdialysis probe insertion into healthy and infected lung tissue, a single intravenous dose of 4 g of fosfomycin was administered. The mean C-max, T-max, AUC(0-4) and AUC(0-infinity) for healthy lung were 131.6 +/- 110.6 mg/L, 1.1 +/- 0.4 h, 242.4 +/- 101.6 mg center dot h/L and 367.6 +/- 111.9 mg center dot h/L, respectively. The corresponding values for infected lung were 107.5 +/- 60.2 mg/L, 1.4 +/- 0.5 h, 203.5 +/- 118.4 mg center dot h/L and 315.1 +/- 151.2 mg center dot h/L. The half-life of fosfomycin ranged from 2.2 to 2.7 h between compartments. The magnitude of lung tissue penetration, as determined by the ratios of the AUC(0-infinity) for lung to the AUC(0-infinity) for plasma, was 0.63 +/- 0.31 and 0.53 +/- 0.31 for healthy and infected lung, respectively. We conclude that fosfomycin achieves antimicrobially effective concentrations in infected lung tissue.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Anti-Bacterial Agents - administration and dosage
- Female -
- Fosfomycin - administration and dosage
- Half-Life -
- Humans -
- Injections, Intravenous -
- Lung - chemistry
- Male -
- Middle Aged -
- Sepsis - drug therapy
- Find related publications in this database (Keywords)
- tissue
- penetration
- human
- microdialysis