Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Juch, H; Dohr, G.
Soluble HLA-G and Assisted Reproductive Technology - An Artefact Used as Basis For a (Vitally) Important Decision?
GEBURTSH FRAUENHEILK. 2010; 70(1): 17-23. Doi: 10.1055/s-0029-1240729
Web of Science FullText FullText_MUG

Leading authors Med Uni Graz: Juch Herbert
Co-authors Med Uni Graz: Dohr Gottfried
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Soluble HLA-G has been proposed as a useful parameter for embryo and probably oocyte viability in ART. But while some clinicians already offer sHLA-G analysis of cultured human embryos to infertile patients using commercially available test systems, there is considerable doubt about the validity of this marker. We present a review of the available data in the literature, which reveals serious technical problems with the detection methods and a critical lack of standardisation and reproducibility. Moreover, the concept of "active secretion of HLA-G" is clearly contradictory to well established concepts of RNA decay. Considering what is known of nonsense mediated RNA decay (NMD), measurable amounts of sHLA-G should not be expected in supernatants of human oocytes and preimplantation embryos at all. To avoid creating "scientific bubbles", the scientific and technical basis needs to be critically investigated before a "newmarker" is introduced in clinics. In our opinion, the decision which oocytes to fertilise and cultivate or which embryos to transfer into the uterus are too important to be based on a probable artefact.
Find related publications in this database (Keywords): soluble HLA-G; assisted reproductive technology; IVF; embryo quality; nonsense mediated RNA decay