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SHR Neuro Cancer Cardio Lipid Metab Microb
Tabiasco, J; Perrier d'Hauterive, S; Thonon, F; Parinaud, J; Léandri, R; Foidart, JM; Chaouat, G; Munaut, C; Lombroso, R; Selva, J; Bergère, M; Hammoud, I; Kozma, N; Aguerre-Girr, M; Swales, AK; Sargent, IL; Le Bouteiller, P; Lédée, N.
Soluble HLA-G in IVF/ICSI embryo culture supernatants does not always predict implantation success: a multicentre study.
Reprod Biomed Online. 2009; 18(3): 374-381.
Doi: 10.1016/S1472-6483(10)60096-X
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- Kozma Noemi
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- Abstract:
- Several reports have described an association between the presence of soluble human leukocyte antigen G (sHLA-G) in human embryo culture supernatants (ES) and implantation success. However, not all studies agree with these findings. To further document this debate, a multicentre blinded study was performed to investigate, on a large number of IVF ES and ICSI ES, whether sHLA-G is a useful criterion for embryo selection before transfer. A total of 1405 ES from 355 patients were collected from three assisted reproductive technique (ART) centres and evaluated for their sHLA-G content in a single laboratory, using a chemiluminescence enzyme-linked immunosorbent assay. In only one centre was a significant association between sHLA-G-positive ES and successful implantation established (P = 0.0379), whereas no such association was observed in the other centres. It was found that the percentages and concentrations of sHLA-G-positive ES varied between centres, depending on culture media and ART conditions. The percentage of sHLA-G-positive ES was significantly higher in IVF ES than ICSI ES (P < 0.001 and P < 0.01 for two centres). These data demonstrate that substantial variations of sHLA-G content in ES occur between different ART centres, highlighting the influence of several technical parameters that differ from one centre to another.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Culture Media -
- Enzyme-Linked Immunosorbent Assay -
- Fertilization in Vitro -
- HLA Antigens - analysis
- Histocompatibility Antigens Class I - analysis
- Humans -
- Luminescence -
- Sperm Injections, Intracytoplasmic -
- Find related publications in this database (Keywords)
- embryo transfer
- ICSI
- IVF
- soluble HLA-G