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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Mittelbronn, M; Capper, D; Bader, B; Schittenhelm, J; Haybaeck, J; Weber, P; Meyermann, R; Kretzschmar, HA; Wietholter, H.
Severe hypoxia and multiple infarctions resembling Creutzfeldt-Jakob disease.
Folia Neuropathol. 2008; 46(2): 149-153.
(- Case Report)
[OPEN ACCESS]
Web of Science
PubMed
- Co-authors Med Uni Graz
- Haybäck Johannes
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- Abstract:
- Although neuropathological examination is still required for the definite diagnosis of Creutzfeldt-Jakob disease (CJD), specialised clinical assessment predicts probable CJD. Here we present a 73-year-old female patient presenting with rapid cognitive decline, visual, acoustic and cerebellar disturbances, ataxia and EEG changes compatible with early CJD stages. MRI revealed hyperintensities within the thalami, hypothalami, corpora mammillaria, the tectum and the cortex. Initial neuropathological examination showed severe cortical and subcortical spongiosis. However, both immunohistochemistry and Western blotting showed no pathological prion protein. Finally, small infarctions affecting the tectum, tegmentum, corpora mammillaria and global hypoxic-ischaemic changes could be identified as the probable reason for the changes interpreted as CJD-related pathology. Hypoxic-ischaemic CNS alterations mainly affecting the supply area of the basilar artery should be ruled out in case of probable CJD. In addition, severe spongiosis can be misleading in the histological examination, suggesting the diagnosis of a prion-induced spongiform encephalopathy.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Brain - blood supply
- Cerebral Cortex - pathology
- Cerebrovascular Circulation - physiology
- Creutzfeldt-Jakob Syndrome - pathology
- Diagnosis, Differential -
- Female -
- Humans -
- Hypothalamus - pathology
- Hypoxia-Ischemia, Brain - pathology
- Magnetic Resonance Imaging -
- Mesencephalon - pathology
- Thalamus - pathology
- Find related publications in this database (Keywords)
- Creutzfeldt-Jakob disease
- hypoxia
- infarction
- mesencephalon
- prion