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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Malli, R; Graier, WF.
Mitochondrial Ca2+ channels: Great unknowns with important functions.
FEBS Lett. 2010; 584(10): 1942-1947.
Doi: 10.1016/j.febslet.2010.01.010
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- Leading authors Med Uni Graz
- Graier Wolfgang
- Malli Roland
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- Abstract:
- Mitochondria process local and global Ca(2+) signals. Thereby the spatiotemporal patterns of mitochondrial Ca(2+) signals determine whether the metabolism of these organelles is adjusted or cell death is executed. Mitochondrial Ca(2+) channels of the inner mitochondrial membrane (IMM) actually implement mitochondrial uptake from cytosolic Ca(2+) rises. Despite great efforts in the past, the identity of mitochondrial Ca(2+) channels is still elusive. Numerous studies aimed to characterize mitochondrial Ca(2+) uniport channels and provided a detailed profile of these great unknowns with important functions. This mini-review revisits previous research on the mechanisms of mitochondrial Ca(2+) uptake and aligns them with most recent findings.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Biological Transport -
- Calcium - metabolism
- Calcium Channels - chemistry
- Humans -
- Mitochondria - metabolism
- Phosphorylation -
- Find related publications in this database (Keywords)
- Calcium signaling
- ER Ca2+ release
- grp75
- IP3 receptor
- Letm1
- mCa1
- mCa2
- MiCa
- MCU
- Mitochondrial Ca2+ uniporter
- Mitofusin
- p38MAPK
- Uncoupling protein
- UCP2/3