Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wascher, TC; Bachernegg, M; Kickenweiz, E; Stark, G; Stark, U; Toplak, H; Graier, WF; Krejs, GJ.
Elevation of D-glucose impairs coronary artery autoregulation after slight reduction of coronary flow.
Eur J Clin Invest. 1995; 25(8):590-594
Doi: 10.1111/j.1365-2362.1995.tb01750.x
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- Führende Autor*innen der Med Uni Graz
- Wascher Thomas
- Co-Autor*innen der Med Uni Graz
- Graier Wolfgang
- Krejs Günter Josef
- Toplak Hermann
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- Abstract:
- Diabetes mellitus is thought to increase the susceptibility of tissue to hypoxic injury through D-glucose-induced alterations of intracellular metabolism. Therefore the effects of hyperglycaemia on coronary artery autoregulation under slight reduction of coronary flow were investigated in isolated perfused guinea-pig hearts. Under normal (10 mM) D-glucose concentrations coronary autoregulation was intact in response to a slight reduction of coronary flow (from 6 to 4.5 mL min-1) when L-arginine as a precursor of the endothelium-derived relaxing factor (EDRF/NO) was available and formation of prostaglandines was intact. Under high (44 mM) D-glucose concentrations on the other hand, a sustained vasodilatation dependent on the availability of L-arginine was observed, when formation of prostaglandins was blocked. This effect was partially reduced in the presence of prostaglandin synthesis. Furthermore, the effect of L-arginine under both conditions could be antagonized by the L-arginine-analogue NG-nitro-L-arginine-methyl-ester (100 microM). Our results suggest that hyperglycaemia impairs coronary artery autoregulation by reducing the threshold for hypoxic vasodilatation in an EDRF/NO-dependent manner. Concomitantly a shift from the formation of vasodilatatory to vasoconstrictive prostaglandines was observed. These results might be of particular interest in patients with diabetes mellitus and ischaemic heart disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anoxia - physiopathology
- Coronary Circulation -
- Coronary Vessels - physiopathology
- Female -
- Guinea Pigs -
- Homeostasis -
- Hyperglycemia - physiopathology
- Male -
- Nitric Oxide - physiology