Medizinische Universität Graz - Research portal
Selected Publication:
Auer, T; Aichhorn, R; Khoschsorur, G; Hobarth, G.
Effect of antioxidative treatment in cardiac bypass operations
In: Pasquier, C. editors(s). XI BIENNIAL MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH INTERNATIONAL; 383-387. (ISBN: 88-323-2716-3) ( Presented at: 11th Biennial Meeting of the Society-for-Free-Radical-Research-International, PARIS, FRANCE, JUL 16-20, 2002)
Web of Science
- Leading authors Med Uni Graz
- Auer-Schönbach Thomas
- Co-authors Med Uni Graz
- Hoebarth Gerhard
- Khoschsorur Gholamali
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- Abstract:
- Introduction: The effect of an antioxidativ treatment has been studied by Malondialdehyd (MDA) and the SH/SS ratio. Methods: of 9 treated (Therapy Group - TG) versus 12 non treated patients (Control Group - CG), Vitamin A-E-C blood levels and MDA and the SH/SS ratio was determinated pre-, during and post operation. In the TG a vitamin cocktail containing A,E,C was administered by iv infusions. Results: Vitamin A and E levels decreased significantly after reperfusion onset without sign. difference between TG and CG. Vitamin C increased (38%) in the CG, a 13 times increase was observed of the TG. After 5 days, CG levels of Vit.C were significantly lower than the base levels before the OP. MDA levels increased during reperfusion. (4times), but no significant difference was observed between the groups in the early reperfusion period.. Conclusion:A significant lower MDA level suggested a positive treatment effect in the late reperfusion period whereas no significance was seen in the early period.