Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Griesbacher, T.
Kinin-induced relaxations of the rat duodenum.
Naunyn Schmiedebergs Arch Pharmacol. 1992; 346(1):102-107
Doi: 10.1007/BF00167578
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- Führende Autor*innen der Med Uni Graz
- Griesbacher Thomas
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- Abstract:
- Both bradykinin (BK) and des-Arg9-BK induced relaxations of the isolated longitudinal smooth muscles of the rat duodenum. No contractile effects were observed with both peptides at concentrations up to 1 mumol/l. Des-Arg9-BK was about 1000 times less potent than BK. The novel B2 antagonist HOE 140 (D-Arg-[Hyp3, Thi5, D-Phe7, Oic8]-BK) potently inhibited the BK-induced relaxations, but did not affect the relaxations induced by des-Arg9-BK. Conversely, the B1 receptor antagonist des-Arg9-[Leu8]-BK only inhibited des-Arg9-BK, but did not affect BK-induced relaxations. The relaxations induced by BK and by des-Arg9-BK were inhibited by apamin (1 mumol/l) demonstrating that apamin-sensitive K+ channels are involved. In contrast, tetraethylammonium (1 mmol/l) did not inhibit the relaxations. BK-induced relaxations were reduced by about 25% in the presence of indomethacin (10 mumol/l) although the concentration-response curve to BK was not shifted to the left. Prostaglandin E1 caused relaxations with a pD2 value of 9.2. It is concluded that both BK and des-Arg9-BK can elicit relaxations of the rat duodenum via pharmacologically distinct kinin receptor subtypes, but via similar effector mechanisms.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Apamin - pharmacology
- Bradykinin - pharmacology
- Duodenum - drug effects
- Female - drug effects
- Indomethacin - pharmacology
- Male - pharmacology
- Muscle Relaxation - drug effects
- Prostaglandins - pharmacology
- Rats - pharmacology
- Receptors, Bradykinin - pharmacology
- Receptors, Neurotransmitter - antagonists and inhibitors
- Tetraethylammonium - antagonists and inhibitors
- Tetraethylammonium Compounds - pharmacology
- Find related publications in this database (Keywords)
- Bradykinin Receptors
- Bradykinin Antagonists
- Hoe 140
- Smooth Muscle Relaxation
- Potassium Channels