Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Nowak-Göttl, U; Auberger, K; Göbel, U; Kreuz, W; Schneppenheim, R; Vielhaber, H; Zenz, W; Zieger, B.
Inherited defects of the protein C anticoagulant system in childhood thrombo-embolism.
Eur J Pediatr. 1996; 155(11):921-927
Doi: 10.1007/BF02282879
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Zenz Werner
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Childhood thrombo-embolism is mostly the result of inherited thrombophilia or vascular insults combined with risk factors such as peripartal asphyxia, fetopathia diabetica, exsiccosis, septicaemia, central lines, congenital heart disease, cancer, trauma, surgery or elevated antiphospholipid antibodies. Inherited thrombophilia includes mainly defects of the protein C pathway, resistance to activated protein C, protein C or protein S deficiency. Resistance to activated protein C, in the majority of cases caused by the point mutation Arg 506 Gln of the factor V gene, has emerged as the most important hereditary cause of thrombo-embolism in adults and children. However, since an acquired risk of thrombo-embolic complications frequently masks the inherited deficiency in affected children, children with thrombo-embolism should have adequate laboratory evaluation for inherited coagulation disorders, especially the protein C pathway. Until more data on childhood thrombo-embolism are available, treatment recommendations will continue to be extrapolated from guidelines for adults.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Coagulation - physiology
- Blood Coagulation Disorders - diagnosis
- Child - diagnosis
- Genetic Screening - diagnosis
- Genotype - diagnosis
- Heterozygote - diagnosis
- Humans - diagnosis
- Mutation - diagnosis
- Phenotype - diagnosis
- Protein C - genetics
- Protein C Deficiency - genetics
- Thromboembolism - genetics
- Find related publications in this database (Keywords)
- Resistance to Activated Protein C (Apcr)
- Protein C
- Protein S
- Childhood Thromboembolism