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Wolf, G; Loidolt, D; Saria, A; Gamse, R.
Changes in nasal volume flow following local administration of neuropeptide substance P and capsaicin
LARYNGOL RHINOL OTOL VER MONA. 1987; 66: 412-415. Doi: 10.1055/s-2007-998692
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Leading authors Med Uni Graz: Wolf Gerald
Co-authors Med Uni Graz: Lang-Loidolt Doris
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Abstract:: In a recently published paper, the author discovered the neuropeptide Substance-P (SP) in human nasal mucosa. SP is the transmitter substance of sensory neurons in the central and peripheral nervous system. The influence of SP and CAPSAICIN on the vascular system of human nasal mucosa is investigated. The application of these substances on the nasal mucosa of volunteers leads to a significant decrease of nasal air flow which can be registered by anterior rhinomanometry. The pathogenetic importance of vascular protein leakage and vasodilatation caused by the neuropeptide SP is discussed.
Find related publications in this database (using NLM MeSH Indexing): Capsaicin - pharmacology; Dose-Response Relationship, Drug - pharmacology; English Abstract - pharmacology; Humans - pharmacology; Manometry - pharmacology; Nasal Mucosa - drug effects; Pulmonary Ventilation - drug effects; Substance P - pharmacology