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Selected Publication:
Leopold, B; Wawschinek, O; Lind, P; Eber, O.
Radioelectrophoresis for determination of thyroid hormone binding abnormalities in human serum.
J CLIN CHEM CLIN BIOCHEM. 1987; 25(7): 431-435.
Doi: 10.1515/cclm.1987.25.7.431
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- Co-authors Med Uni Graz
- Tiran Beate
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- Abstract:
- This paper describes a rapid and accurate method for determining binding abilities of thyroid hormones to their corresponding serum proteins: prealbumin, albumin and thyroxine binding globulin. A tube cell agarose gel electrophoresis is used with radioactive labelled triiodothyronine or thyroxine. The distribution curve shows characteristic peaks for prealbumin, albumin and thyroxine binding globulin. A collective of 60 euthyroid thyroid-healthy persons was examined, and the following reference values for the binding of thyroxine to its binding proteins were found: The percentage binding of thyroxine to the prealbumin fraction is 21 to 33%, to the albumin fraction 10 to 15% and to the thyroxine binding globulin fraction 54 to 66%. In a group of 220 patients with suspected thyroid hormone binding abnormalities there were 42 cases of albumin-associated hyperthyroxinaemia, 5 cases of prealbumin-associated hyperthyroxinaemia and 2 cases of thyroxine binding globulin deficiency. In another group of 35 patients with suspected antibodies against thyroid hormones one patient showed antibodies against triiodothyronine.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Proteins - metabolism
- Electrophoresis, Agar Gel - metabolism
- Humans - metabolism
- Prealbumin - metabolism
- Protein Binding - metabolism
- Thyroid Hormones - blood
- Thyroxine - metabolism
- Thyroxine-Binding Proteins - analysis
- Triiodothyronine - metabolism