Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Winklhofer-Roob, BM; Tiran, B; Tuchschmid, PE; van't Hof, MA; Shmerling, DH.
Effects of pancreatic enzyme preparations on erythrocyte glutathione peroxidase activities and plasma selenium concentrations in cystic fibrosis.
Free Radic Biol Med. 1998; 25(2):242-249
Doi: 10.1016%2FS0891-5849%2898%2900061-6
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- Co-Autor*innen der Med Uni Graz
- Tiran Beate
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- Abstract:
- To substitute for exocrine pancreatic insufficiency, patients with cystic fibrosis (CF) take pancreatic enzymes (PE) originating from porcine pancreas. Five different pancreatic enzyme preparations used by our patients contained 0.5-1.4 microg selenium per g tablet. In patients taking PE in doses that were gradually increased to improve fat absorption during a 48-month period, the effects of PE dose on erythrocyte selenium-dependent glutathione peroxidase (SeGSH-Px) activities and plasma selenium concentrations were studied. At baseline, erythrocyte SeGSH-Px activities were significantly lower in patients (p=.01), while plasma selenium concentrations did not differ between patients and healthy subjects. When PE dose and, consequently, selenium intake from PE was increased, erythrocyte SeGSH-Px activities (p < .001) and plasma selenium concentrations (p=.02) increased. Changes in SeGSH-Px activities during the initial 8 months correlated with those in selenium intake from PE (r=0.67, p < .001). Plasma selenium concentrations plateaued at 12 months and erythrocyte SeGSH-Px activities did so at 36 months, when patients had reached SeGSH-Px activities similar to those of healthy subjects. At 48 months, patients took an average lipase dose of 17400 U x kg(-1) x d(-1) and selenium dose from PE of 0.53 microg x kg(-1) x d(-1). We conclude that selenium content of PE preparations has a significant effect on SeGSH-Px activity in patients with CF. This form of selenium supply needs to be taken into account when selenium supplements are given to patients with CF.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Adolescent -
- Adult -
- Child -
- Child, Preschool -
- Cross-Sectional Studies -
- Cystic Fibrosis - blood
- Dose-Response Relationship, Drug - blood
- Drug Administration Schedule - blood
- Enzyme Activation - drug effects
- Enzymes - pharmacology
- Erythrocytes - drug effects
- Female - drug effects
- Glutathione Peroxidase - analysis
- Humans - analysis
- Infant - analysis
- Lipase - administration and dosage
- Longitudinal Studies - administration and dosage
- Male - administration and dosage
- Pancreatic Extracts - administration and dosage
- Pancreatin - administration and dosage
- Pancrelipase - administration and dosage
- Selenium - analysis
- Find related publications in this database (Keywords)
- Selenium
- Glutathione Peroxidase
- Plasma Concentrations
- Erythrocytes
- Pancreatic Enzymes
- Cystic Fibrosis
- Healthy Subjects
- Swiss