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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Calayir, E; Becker, TM; Kratzer, A; Ebner, B; Panzenböck, U; Stefujl, J; Kostner, GM.
LXR-agonists regulate ApoM expression differentially in liver and intestine.
Curr Pharm Biotechnol. 2008; 9(6): 516-521.
Doi: 10.2174/138920108786786376
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- Leading authors Med Uni Graz
- Kostner Gerhard
- Co-authors Med Uni Graz
- Becker Tatjana
- Gallé Birgit
- Kratzer Adelheid
- Panzenboeck Ute
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- Abstract:
- Apolipoprotein M (apoM) has been suggested to play a role in reverse cholesterol transport. Here we studied the influence of liver X-receptor (LXR) agonist on the transcriptional regulation of apoM. Studies were performed in murine liver and intestinal mucosal cells in vivo and in human intestinal Caco-2 cells in vitro. The expression of apoM was analyzed by quantitative real time PCR, and compared to well-established LXR target genes. Mice fed with TO901317 for six days showed a downregulation of apoM and apoAI in the liver to 40 % and 60 % respectively and an upregulation of Cyp7A1 to 280 %. In the small intestine, however, apoM and apoAI were upregulated by 30-60 % and ABCA1 by 250-430 %. In Caco-2 cells TO901317 caused a 60 % upregulation and the natural LXR agonist 22-hydroxycholesterol a 40 % upregulation of apoM. Possible causes for the differential effects in liver and intestine are discussed.
- Find related publications in this database (using NLM MeSH Indexing)
- Apolipoproteins - metabolism
- Caco-2 Cells -
- DNA-Binding Proteins - drug effects DNA-Binding Proteins - metabolism
- Gene Expression Regulation - drug effects Gene Expression Regulation - physiology
- Humans -
- Hydrocarbons, Fluorinated - administration and dosage
- Intestines - drug effects Intestines - metabolism
- Liver - drug effects Liver - metabolism
- Organ Specificity - drug effects Organ Specificity - physiology
- Receptors, Cytoplasmic and Nuclear - drug effects Receptors, Cytoplasmic and Nuclear - metabolism
- Signal Transduction - drug effects Signal Transduction - physiology
- Sulfonamides - administration and dosage
- Find related publications in this database (Keywords)
- Intestine
- lipid metabolism
- lipocalin
- expression profiling