Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Mannweiler, S; Amersdorfer, P; Trajanoski, S; Terrett, JA; King, D; Mehes, G.
Heterogeneity of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Carcinoma with Distant Metastasis.
Pathol Oncol Res. 2009; 15(2):167-172
Doi: 10.1007/s12253-008-9104-2
Web of Science
PubMed
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FullText_MUG
- Leading authors Med Uni Graz
- Mannweiler Sebastian
- Co-authors Med Uni Graz
- Trajanoski Slave
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- Abstract:
- Prostate-specific membrane antigen (PSMA) is a transmembrane protein that is overexpressed in advanced stage prostate adenocarcinomas. As a novel target for in vivo prognostic and therapeutic approaches, the distribution pattern of PSMA in primary and metastatic tumors is of significant interest. In this study we addressed the cellular distribution and heterogeneity of PSMA expression. Paraffin-embedded sections of 51 patients with primary prostate carcinoma and distant metastases were evaluated. Immunohistochemistry was used to determine the cellular localization, staining intensity and positive cell fraction which were related to tumor type and growth pattern. We demonstrated differences in the intracellular localization of the PSMA immunostaining which seem to be related to the tumor differentiation pattern. A significant number of the primary tumors (7/51) and metastases (6/51) presented with highly heterogeneous PSMA expression and in further 2 primary, and 8 metastatic tumors the staining was in the negative range (<10% positive tumor cells). A direct correlation between histological parameters and PSMA expression could not be demonstrated. Our findings clearly support the feasibility but also direct to potential failures of PSMA-targeted in vivo diagnostic and therapeutic approaches in prostate cancer patients with distant metastasis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - metabolism Adenocarcinoma - secondary
- Aged -
- Aged, 80 and over -
- Antigens, Surface - metabolism
- Cell Differentiation -
- Cell Membrane - metabolism
- Cytoplasm - metabolism
- Glutamate Carboxypeptidase II - metabolism
- Humans -
- Immunoenzyme Techniques -
- Male -
- Middle Aged -
- Prognosis -
- Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology
- Find related publications in this database (Keywords)
- Prostate cancer
- Antibody
- Immunohistochemistry
- Therapy