Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Donnerer, J; Lembeck, F.
Capsaicin-induced reflex fall in rat blood pressure is mediated by afferent substance P-containing neurones via a reflex centre in the brain stem.
Naunyn Schmiedebergs Arch Pharmacol. 1983; 324(4):293-295
Doi: 10.1007/BF00502626
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- Führende Autor*innen der Med Uni Graz
- Donnerer Josef
- Co-Autor*innen der Med Uni Graz
- Lembeck Fred
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- Abstract:
- Injection of 0.03 micrograms capsaicin into one femoral artery elicited a fall in blood pressure in the rat. This effect was completely and reversibly abolished following intrathecal injection of 1 nmol of the specific substance P antagonist, [D-Pro2,D-Trp7,9] substance P. The capsaicin-evoked depressor reflex is therefore exclusively mediated by substance P-containing primary afferent fibres. Using spinal rats or decerebration experiments, the centre of the capsaicin-evoked reflex fall in blood pressure could be localized in the brain stem.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blood Pressure - drug effects
- Brain Stem - drug effects
- Capsaicin - pharmacology
- Decerebrate State - pharmacology
- Injections, Intra-Arterial - pharmacology
- Injections, Spinal - pharmacology
- Male - pharmacology
- Neurons, Afferent - drug effects
- Rats - drug effects
- Reflex - drug effects
- Substance P - analogs and derivatives