Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Colpaert, FC; Donnerer, J; Lembeck, F.
Effects of capsaicin on inflammation and on the substance P content of nervous tissues in rats with adjuvant arthritis.
Life Sci. 1983; 32(16):1827-1834
Doi: 10.1016/0024-3205(83)90060-7
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- Co-Autor*innen der Med Uni Graz
- Donnerer Josef
- Lembeck Fred
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- Abstract:
- Capsaicin (20-80 mg/kg, s.c.) reduced the inflammatory response to inoculation with Mycobacterium butyricum in the rat. The effect was apparent within 24 h, was partial, persisted for well over 20 days, and occurred irrespective of whether capsaicin was administered before or after the onset of inflammation, or at the time when the pathology reached peak. Capsaicin also attenuated the increase in substance P content in sciatic nerve, saphenous nerve, dorsal root ganglia, dorsal roots, and dorsal spinal cord (L4, L5) which occurs in rats with adjuvant arthritis. The data are consistent with a possible role of substance P in the peripheral manifestations of adjuvant arthritis.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Arthritis - physiopathology
- Arthritis, Experimental - physiopathology
- Capsaicin - pharmacology
- Fatty Acids, Unsaturated - pharmacology
- Inflammation - pharmacology
- Kinetics - pharmacology
- Male - pharmacology
- Mycobacterium - pharmacology
- Nervous System - drug effects
- Rats - drug effects
- Rats, Inbred Strains - drug effects
- Substance P - metabolism