Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Lembeck, F; Donnerer, J; Barthó, L.
Inhibition of neurogenic vasodilation and plasma extravasation by substance P antagonists, somatostatin and D-Met2, Pro5enkephalinamide.
Eur J Pharmacol. 1982; 85(2):171-176
Doi: 10.1016/0014-2999(82)90462-9
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- Führende Autor*innen der Med Uni Graz
- Lembeck Fred
- Co-Autor*innen der Med Uni Graz
- Donnerer Josef
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- Abstract:
- The substance P (SP) analogues [D-Pro2, D-Phe7, D-Trp9]SP and [D-Pro2, D-Trp7,9]SP, which have been reported to be SP antagonists, inhibited the vasodilation and plasma extravasation induced by antidromic stimulation of the saphenous nerve or by i.a. infusion of SP. Somatostatin inhibited the vasodilatation and plasma extravasation induced by saphenous nerve stimulation, but had no effect on the vascular responses to i.a. infused SP. The opiate agonist [D-Met2, Pro5]enkephalinamide inhibited the vasodilation evoked by antidromic nerve stimulation in a naloxone reversible manner, but did not change the effect of i.a. infusion of SP. Calcitonin and caerulein had no effect on neurogenic vasodilatation. These results further support the concepts that neurogenic vasodilatation and plasma extravasation are mediated by SP, and that somatostatin and opiates inhibit the release of SP from peripheral sensory nerve endings.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Enkephalin, Methionine - analogs and derivatives
- Female - analogs and derivatives
- Male - analogs and derivatives
- Peripheral Nerves - physiology
- Plasma - drug effects
- Rats - drug effects
- Somatostatin - pharmacology
- Substance P - antagonists and inhibitors
- Vasodilation - drug effects