Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Gamse, R; Saria, A; Bucsics, A; Lembeck, F.
Substance P in tumors: pheochromocytoma and carcinoid.
PEPTIDES. 1981; 2 Suppl 2(6): 275-280.
Doi: 10.1016/0196-9781(81)90045-0
(- Case Report)
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-Autor*innen der Med Uni Graz
- Lembeck Fred
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Immunoreactive substance P (I-SP) was measured in two pheochromocytomas and a carcinoid of the caecum. The pheochromocytomas contained 1,5 and 50 pmol/g I-SP respectively. An HPLC analysis I-SP and catecholamines were enriched in the chromaffin granule fraction. The carcinoid contained 2900 pmol/g I-SP. About 40% of the immunoreactivity behaved like substance P on gel filtration, HPLC and in bioassays (fall in rabbit blood pressure and contraction of the guinea-pig ileum which was abolished by specific tachyphylaxis to substance P). These results indicate that authentic substance P is present in carcinoids and pheochromocytomas and that in the latter it is most likely stored in chromaffin granules.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenal Gland Neoplasms - metabolism
- Animals - metabolism
- Biological Assay - metabolism
- Blood Pressure - drug effects
- Carcinoid Tumor - metabolism
- Catecholamines - metabolism
- Cecal Neoplasms - metabolism
- Chromaffin Granules - metabolism
- Chromatography, High Pressure Liquid - metabolism
- Female - metabolism
- Guinea Pigs - metabolism
- Humans - metabolism
- Male - metabolism
- Muscle Contraction - drug effects
- Pheochromocytoma - metabolism
- Rabbits - metabolism
- Rats - metabolism
- Somatostatin - metabolism
- Substance P - metabolism