Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Beham, A; Ratschek, M; Zatloukal, K; Schmid, C; Denk, H.
Distribution of cytokeratins, vimentin and desmoplakins in normal renal tissue, renal cell carcinomas and oncocytoma as revealed by immunofluorescence microscopy.
Virchows Arch A Pathol Anat Histopathol. 1992; 421(3):209-215
Doi: 10.1007/BF01611177
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Beham Alfred
- Co-Autor*innen der Med Uni Graz
- Denk Helmut
- Ratschek Manfred
- Zatloukal Kurt
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Forty-two renal cell carcinomas, one oncocytoma and normal renal tissue were studied for the presence of cytokeratins and vimentin. The investigations were performed by immunofluorescence microscopy applying a panel of mono- and polyclonal antibodies to intermediate filament proteins. In all tumours except chromophobic renal cell carcinoma (CRCC) and oncocytoma a co-expression of cytokeratins and vimentin could be shown. The intermediate filament expression was often, however, very heterogeneous particularly with respect to the distribution of cytokeratins and vimentin, to the clonality of the antibodies used and to the tumour areas studied. The latter could be impressively demonstrated by examining a whole tumour. In CRCC and oncocytoma all tumour cells expressed cytokeratins and, in addition, single tumour cells also expressed vimentin. In normal renal tissue we could show vimentin-positive epithelia of proximal and distal tubules, which is reported for the first time.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenoma - chemistry
- Carcinoma, Renal Cell - chemistry
- Cytoskeletal Proteins - analysis
- Desmoplakins - analysis
- Epithelium - chemistry
- Fluorescent Antibody Technique - chemistry
- Humans - chemistry
- Intermediate Filament Proteins - analysis
- Keratins - analysis
- Kidney Neoplasms - chemistry
- Kidney Tubules, Distal - chemistry
- Kidney Tubules, Proximal - chemistry
- Vimentin - analysis