Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Bucsics, A; Lembeck, F.
In vitro release of substance P from spinal cord slices by capsaicin congeners.
EUR J PHARMACOL. 1981; 71(1): 71-77.
Doi: 10.1016/0014-2999(81)90387-3
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- Co-Autor*innen der Med Uni Graz
- Lembeck Fred
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- Abstract:
- The in vitro release of immunoreactive substance P (I-SP) by capsaicin and three congeners was studied on slices of rat spinal cord upper dorsal horn. Capsaicin and its congeners were all able to stimulate I-SP release, indicating that they act on chemosensitive primary afferents terminating in this region. A positive correlation was found between the I-SP releasing and pain-producing potencies of these compounds. This is in agreement with the concept that primary afferents containing substance P (SP) are involved in the transmission of nociceptive information.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Capsaicin - analogs and derivatives
- Dose-Response Relationship, Drug - analogs and derivatives
- Fatty Acids, Unsaturated - pharmacology
- Female - pharmacology
- Ganglia, Spinal - metabolism
- Male - metabolism
- Rats - metabolism
- Spinal Cord - drug effects
- Substance P - biosynthesis