Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Fruhwald, S; Holzer, P; Metzler, H.
Gastrointestinal motility in acute illness.
Wien Klin Wochenschr. 2008; 120(1-2): 6-17.
Doi: 10.1007/s00508-007-0920-2
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- Leading authors Med Uni Graz
- Fruhwald Sonja
- Co-authors Med Uni Graz
- Holzer Peter
- Metzler Helfried
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- Abstract:
- Critical illness affects gastrointestinal motility - not only as a primary problem, which brings the patient to the intensive care unit (ICU), but also as a complication consecutive to the ICU stay. Motility disturbances may result from impaired function of gastrointestinal muscle, pacemaker cell function and nerve activity. The most important neural control system is the enteric nervous system that contains the largest collection of neurons (10(8) cells) outside the central nervous system. Through its organization it can operate independently of the brain and generate motility patterns according to need: a postprandial motility pattern starting after food intake, and an interdigestive motility pattern starting several hours after a meal. Undisturbed intestinal motility depends critically on a balanced interaction between inhibition and excitation, and a disturbance in this balance leads to severe derangements of intestinal motility. These motility disturbances differ in clinical appearance and location but can affect all parts of the gastrointestinal tract. This review focuses on select motility disturbances such as gastroparesis, postoperative ileus, and Ogilvie's syndrome. Generally effective methods to treat these conditions are given. Finally, we focus on special management options to prevent such motility disturbances or to reduce their severity.
- Find related publications in this database (using NLM MeSH Indexing)
- Algorithms -
- Colonic Pseudo-Obstruction - etiology
- Combined Modality Therapy -
- Critical Care - methods
- Critical Illness -
- Enteric Nervous System - physiopathology
- Gastrointestinal Agents - therapeutic use
- Gastrointestinal Diseases - etiology
- Gastrointestinal Motility - physiology
- Gastroparesis - etiology
- Humans -
- Ileus - etiology
- Intensive Care Units -
- Myoelectric Complex, Migrating - physiology
- Postoperative Complications - etiology
- Find related publications in this database (Keywords)
- intestinal motility
- migrating motor complex
- postoperative ileus
- Ogilvie's syndrome
- prokinetic drugs