Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Mayer, N; Gamse, R; Lembeck, F.
Effect of capsaicin pretreatment on substance P binding to synaptic vesicles.
J NEUROCHEM. 1980; 35(5): 1238-1241.
Doi: 10.1111/j.1471-4159.1980.tb07881.x
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- Co-Autor*innen der Med Uni Graz
- Lembeck Fred
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- Abstract:
- Newborn or adult rats were pretreated with 50 mg kg-1 capsaicin. At the age of 2 to 4 months, binding of 125I-labelled Tyr8-substance P to synaptic vesicles prepared from different regions of the nervous system was examined. In both groups, capsaicin pretreatment led to a significant decrease in the number of binding sites in dorsal roots and spinal cord without having an effect on affinity. This decrease parallels the depletion of the substance P content (Gamse et al., 1980) and can be explained by degeneration of primary sensory neurons in newborn treated rats and by depletion of vesicles in adult treated rats.
- Find related publications in this database (using NLM MeSH Indexing)
- Aging -
- Animals -
- Animals, Newborn -
- Binding Sites - drug effects
- Brain - metabolism
- Capsaicin - pharmacology
- Fatty Acids, Unsaturated - pharmacology
- Female - pharmacology
- Male - pharmacology
- Rats - pharmacology
- Spinal Cord - metabolism
- Spinal Nerve Roots - metabolism
- Substance P - metabolism
- Synaptic Vesicles - metabolism