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Selected Publication:
Sedlmayr, P; Schallhammer, L; Hammer, A; Wilders-Truschnig, M; Wintersteiger, R; Dohr, G.
Differential phenotypic properties of human peripheral blood CD56dim+ and CD56bright+ natural killer cell subpopulations.
Int Arch Allergy Immunol. 1996; 110(4):308-313
Doi: 10.1159/000237321
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- Leading authors Med Uni Graz
- Sedlmayr Peter
- Co-authors Med Uni Graz
- Dohr Gottfried
- Hammer Astrid
- Truschnig-Wilders Martini
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- Abstract:
- We investigated the presence of integrins and various other cell surface markers on the surface of freshly isolated CD56dim+ and CD56bright+ NK cells, the latter comprising a mean of 6.5% of total peripheral blood (PB) CD3-CD56+ NK cells. This small subpopulation stained more intensively for CD2, CD11c, CD15s, CD44, CD49e, CD55, CD62L, HLA-DR, and GZS-1, whereas there was no expression of CD49f in contrast to CD56dim+ cells. The myeloid antigen CDw65 was present on 11% of CD56bright+ cells, other myeloid markers were not found. 28% of CD56bright+ cells were positive for CD45R0. These results support the notion that CD56bright+ NK cells, based on their different marker profile, may possess different functional and biodistributional properties and--due to the signal-transducing capabilities of several adhesion molecules--differential patterns of stimulatability compared to the majority of PB-NK cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Antigens, CD - analysis
- Antigens, CD56 - analysis
- Biological Markers - analysis
- Cell Adhesion Molecules - analysis
- Female - analysis
- Humans - analysis
- Immunophenotyping - analysis
- Killer Cells, Natural - classification
- Male - classification
- Find related publications in this database (Keywords)
- NK Cells
- Adhesion Molecules
- CAM
- Activation Markers
- Flow Cytometry