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SHR Neuro Cancer Cardio Lipid Metab Microb
März, W; Scharnagl, H; Winkler, K; Tiran, A; Nauck, M; Boehm, BO; Winkelmann, BR.
Low-density lipoprotein triglycerides associated with low-grade systemic inflammation, adhesion molecules, and angiographic coronary artery disease: the Ludwigshafen Risk and Cardiovascular Health study.
Circulation. 2004; 110(19):3068-3074
Doi: 10.1161/01.CIR.0000146898.06923.80
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- Leading authors Med Uni Graz
- März Winfried
- Co-authors Med Uni Graz
- Scharnagl Hubert
- Tiran Andreas
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- Abstract:
- BACKGROUND: Markers of systemic inflammation and LDL cholesterol (LDL-C) have been considered independent risk factors of coronary artery disease (CAD). We examined whether alterations of LDL metabolism not reflected by LDL-C were associated with low-grade inflammation, vascular injury, and CAD. METHODS AND RESULTS: We studied 739 subjects with stable angiographic CAD and 570 matched control subjects in which CAD had been ruled out by angiography. The association of LDL triglycerides (LDL-TGs) (odds ratio [OR], 1.30; 95% CI, 1.19 to 1.43; P<0.001) with CAD was stronger than that of LDL-C (OR, 1.10; 95% CI, 1.00 to 1.21; P=0.047). The predictive value of LDL-TG for CAD was independent of LDL-C. "Sensitive" C-reactive protein (CRP), serum amyloid A, fibrinogen, interleukin 6, intercellular adhesion molecule-1 (ICAM-1), and vascular adhesion molecule-1 (VCAM-1) increased in parallel to LDL-TG. CRP, ICAM-1, and VCAM-1 were inversely related to LDL-C. To examine whether LDL-TGs were associated with the distribution of LDL subfractions, we studied 114 individuals with impaired fasting glucose, impaired glucose tolerance, or type 2 diabetes mellitus. In subjects with high LDL-TG, LDLs were depleted of cholesteryl esters (CEs), and VLDLs, IDLs, and dense LDLs were significantly elevated. CONCLUSIONS: Alterations of LDL metabolism characterized by high LDL-TG are related to CAD, systemic low-grade inflammation, and vascular damage. High LDL-TGs are indicative of CE-depleted LDL, elevated IDL, and dense LDL. LDL-TG may better reflect the atherogenic potential of LDL than LDL-C.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Apolipoproteins B - blood
- C-Reactive Protein - analysis
- Cholesterol Esters - blood
- Cohort Studies - blood
- Coronary Disease - blood
- Cross-Sectional Studies - blood
- Diabetes Complications - blood
- Female - blood
- Germany - blood
- Humans - blood
- Inflammation - blood
- Intercellular Adhesion Molecule-1 - blood
- Interleukin-6 - blood
- Lipoproteins - blood
- Lipoproteins, HDL - blood
- Lipoproteins, IDL - blood
- Lipoproteins, LDL - blood
- Lipoproteins, VLDL - blood
- Male - blood
- Middle Aged - blood
- Predictive Value of Tests - blood
- Risk Factors - blood
- Serum Amyloid A Protein - analysis
- Vascular Cell Adhesion Molecule-1 - blood
- Find related publications in this database (Keywords)
- cholesterol
- triglycerides
- lipoproteins
- inflammation