Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Sovic, A; Balazs, Z; Hrzenjak, A; Reicher, H; Panzenboeck, U; Malle, E; Sattler, W.
Scavenger receptor class B, type I mediates uptake of lipoprotein-associated phosphatidylcholine by primary porcine cerebrovascular endothelial cells.
NEUROSCI LETT. 2004; 368(1): 11-14.
Doi: 10.1016/j.neulet.2004.04.097
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- Leading authors Med Uni Graz
- Sattler Wolfgang
- Co-authors Med Uni Graz
- Hinteregger Helga
- Hrzenjak Andelko
- Malle Ernst
- Panzenboeck Ute
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- Abstract:
- We previously reported that scavenger receptor class B, type I (SR-BI) mediates uptake of lipoprotein-associated cholesteryl ester and Vitamin E by porcine brain capillary endothelial cells (pBCECs). In the present study we investigated whether SR-BI is capable of mediating phosphatidylcholine (PC) uptake by pBCECs from low- and high density lipoproteins. SR-BI-overexpressing CHO cells and pBCECs showed significantly enhanced uptake rates of PC from both lipoprotein classes. In addition, preincubation of pBCECs in the presence of both lipoprotein species resulted in a significant increase of the cellular fatty acid content, particularly linoleic and arachidonic acid. Our results suggest that uptake of lipoprotein-associated PC by the cerebrovasculature via SR-BI could generate a pool of lipids containing polyunsaturated fatty acids available for transport into deeper regions of the brain.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antigens, CD36 -
- CHO Cells -
- Capillaries - cytology
- Cerebrovascular Circulation - physiology
- Cricetinae - physiology
- Culture Media, Serum-Free - physiology
- Endothelial Cells - metabolism
- Fatty Acids, Unsaturated - metabolism
- Humans - metabolism
- Lipoproteins - metabolism
- Lipoproteins, HDL - metabolism
- Lipoproteins, LDL - metabolism
- Phosphatidylcholines - metabolism
- Receptors, Immunologic - physiology
- Receptors, Scavenger - physiology
- Scavenger Receptors, Class B - physiology
- Swine - physiology
- Find related publications in this database (Keywords)
- SR-BI
- phospholipids
- HDL
- LDL
- brain endothelial cells
- selective lipid uptake