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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Matzi, V; Maier, A; Woltsche, M; Smolle-Jüttner, FM.
Polyhematoporphyrin-mediated photodynamic therapy and decortication in palliation of malignant pleural mesothelioma: a clinical pilot study.
Interact Cardiovasc Thorac Surg. 2004; 3(1): 52-56.
Doi: 10.1016/S1569-9293(03)00213-5
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- Leading authors Med Uni Graz
- Maier Alfred
- Matzi Veronika
- Co-authors Med Uni Graz
- Smolle-Juettner Freyja-Maria
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- Abstract:
- The aim of this study was to evaluate the additional effect of intraoperative photodynamic therapy (PDT) under hyperbaric oxygenation (HBO) when compared with decortication alone. From 1/1993 to 8/2002, palliation with decortication was done in 25 patients suffering from advanced malignant pleural mesothelioma. Fourteen patients received additional intraoperative PDT under HBO. The surgery and PDT/HBO was done 48 h after photosensitization with a polyhematoporphyrin, 2 mg/kg/BW using a diode laser delivering red light at 630 nm through a microlens. The light dose was calculated for 300 J with a distance of 1 cm from the tumor surface. At 6-month follow up local tumor control and survival showed a significant difference in both groups. Although the study only includes a small number of patients not allowing definite conclusions, it indicates that the additional PDT/HBO represents a safe and technically feasible approach in the palliative setting of advanced malignant mesothelioma of the pleura.