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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Weingrill, E; Wölfler, A; Strunk, D; Linkesch, W; Sill, H; Liebmann, PM.
Roscovitine in B-chronic lymphocytic leukemia cells: high apoptosis-inducing efficacy and synergism with alemtuzumab independent of the patients' pretreatment status.
Haematologica. 2007; 92(9): 1286-1288.
Doi: 10.3324/haematol.10680
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- Leading authors Med Uni Graz
- Liebmann-Holzmann Peter
- Co-authors Med Uni Graz
- Linkesch Werner
- Sill Heinz
- Strunk Dirk
- Wölfler Albert
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- Abstract:
- Roscovitine induced apoptosis in isolated B-chronic lymphocytic leukemia cells of 25 patients of whom nine with relapsed and seven with fludarabine-refractory disease. It was synergistic with alemtuzumab and restored sensitivity to alemtuzumab in initially alemtuzumab-resistant samples. Observed roscovitine-induced up-regulation of CD52 surface expression may be one of the underlying mechanisms for this synergism.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Antibodies, Monoclonal - administration and dosage
- Antibodies, Neoplasm - administration and dosage
- Antigens, CD - metabolism
- Antigens, Neoplasm - metabolism
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Apoptosis - drug effects
- Cohort Studies - drug effects
- Drug Synergism - drug effects
- Female - drug effects
- Glycoproteins - metabolism
- Humans - metabolism
- Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy
- Male - drug therapy
- Middle Aged - drug therapy
- Mitoxantrone - administration and dosage
- Purines - administration and dosage
- Salvage Therapy - administration and dosage
- Find related publications in this database (Keywords)
- B-CLL
- roscovitine
- alemtuzumab
- apoptosis
- synergism