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SHR Neuro Cancer Cardio Lipid Metab Microb
Schaffler, GJ; Wolf, G; Schoellnast, H; Groell, R; Maier, A; Smolle-Jüttner, FM; Woltsche, M; Fasching, G; Nicoletti, R; Aigner, RM.
Non-small cell lung cancer: evaluation of pleural abnormalities on CT scans with 18F FDG PET.
RADIOLOGY. 2004; 231(3): 858-865.
Doi: 10.1148/radiol.2313030785
[OPEN ACCESS]
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Schaffler Gottfried
- Co-authors Med Uni Graz
- Aigner Reingard
- Groell Reinhard
- Maier Alfred
- Nicoletti Rudolf
- Schoellnast Helmut
- Smolle-Juettner Freyja-Maria
- Wolf Gerhard
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- Abstract:
- PURPOSE: To evaluate the accuracy of fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) in differentiation of pleural malignancy and cancer-unrelated pleural disease in patients with non-small cell lung cancer (NSCLC) and pleural abnormalities at computed tomography (CT). MATERIALS AND METHODS: In 92 patients, pleural abnormalities were detected at contrast material-enhanced thoracic CT, which was performed for newly diagnosed NSCLC (n = 41) or restaging (n = 51). CT findings were negative for pleural malignancy when pleural effusion with attenuation of 10 HU or less and/or rib fractures with no evidence of pathologic fracture were present; findings were indeterminate when pleural effusion with attenuation greater than 16 HU and/or solid pleural abnormalities without osseous destruction of the chest wall were present; and findings were positive if any osseous destruction of the chest wall adjacent to a pleural mass was present. All patients underwent FDG PET. Findings were negative for pleural malignancy if pleural activity was absent, equal to, or less than mediastinal background activity; findings were positive if pleural activity was higher than mediastinal background activity. Reading of CT and FDG PET scans was first performed, separately and then was combined. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPP), and accuracy were calculated for CT and FDG PET separately and for CT and FDG PET combined, with cytologic and/or histologic analysis as standard of reference. RESULTS: In detection of pleural malignancies, CT findings were indeterminate in 65 (71%) patients and true-negative in 27 (29%). Respective sensitivity, specificity, PPV, NPV, and accuracy of FDG PET in detection of pleural malignancies were 100%, 71%, 63%, 100%, and 80%; and those of CT and FDG PET combined, 100%, 76%, 67%, 100%, and 84%. CONCLUSION: Findings suggest that a negative FDG PET scan for indeterminate pleural abnormalities at CT indicates a benign character, while positive findings on an FDG PET scan are sensitive for malignancy. (C) RSNA, 2004.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Carcinoma, Non-Small-Cell Lung - complications Carcinoma, Non-Small-Cell Lung - therapy
- Contrast Media -
- Diagnosis, Differential -
- Female -
- Fluorodeoxyglucose F18 - diagnostic use
- Humans -
- Image Processing, Computer-Assisted -
- Lung Neoplasms - complications Lung Neoplasms - therapy
- Male -
- Middle Aged -
- Pleural Diseases - complications Pleural Diseases - radiography Pleural Diseases - radionuclide imaging
- Pleural Neoplasms - radiography Pleural Neoplasms - radionuclide imaging
- Predictive Value of Tests -
- Radiopharmaceuticals - diagnostic use
- Retrospective Studies -
- Sensitivity and Specificity -
- Tomography, Emission-Computed -
- Tomography, X-Ray Computed -
- Find related publications in this database (Keywords)
- lung neoplasms
- lung neoplasms
- CT
- lung neoplasms
- PET
- pleura
- CT
- pleura
- neoplasms
- pleura
- PET