Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Becker, H; Wirnsberger, G; Ziervogel, K; Höfler, H.
Immunohistochemical markers in (ganglio)neuroblastomas.
Acta Histochem Suppl. 1990; 38(2):107-114
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- Co-Autor*innen der Med Uni Graz
- Wirnsberger Gerhard
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- Abstract:
- 17 commercially available antibodies were applied on formalin fixed and paraffin embedded tissues of neuroblastomas (NBLs, n = 20), ganglioneuroblastomas (GNBLs, n = 7) and ganglioneuromas (GNs, n = 7), to assess their reliability as markers for neuroendocrine differentiation and the degree of tumor cell maturation. Our results indicate, that antibodies directed to neuron specific enolase, HISL 19, dopamine beta-hydroxylase, neurofilament, EGC, LK2H10 and leucocyte common antigen may be useful in discrimination of neuroblastomas from non-neuroendocrine round and small cell tumors in routinely processed tissue. Antibodies to neuron specific enolase, EGC, PGP 9.5, VIP, and S 100 protein may contribute to the determination of the maturation grade of (ganglio)neuroblastomas.
- Find related publications in this database (using NLM MeSH Indexing)
- Cell Differentiation -
- Chromogranins - analysis
- Ganglioneuroma - pathology
- Humans - pathology
- Immunohistochemistry - pathology
- Nerve Tissue Proteins - analysis
- Neuroblastoma - pathology
- Neurosecretory Systems - pathology
- Tumor Markers, Biological - analysis