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Selected Publication:
Iberer, F; Tscheliessnigg, K; Halwachs, G; Auer, T; Wasler, A; Petutschnigg, B; Schreier, G; Müller, H; Allmayer, T; Prenner, G.
Cytomegalovirus after heart transplantation: definitions for the guidance of antiviral therapy.
Scand J Infect Dis Suppl. 1995; 99(3):100-103
Web of Science
PubMed
- Leading authors Med Uni Graz
- Iberer Florian
- Co-authors Med Uni Graz
- Allmayer Thomas
- Auer-Schönbach Thomas
- Baumann Gabriele
- Müller Helmut
- Petutschnigg Berthold
- Prenner Günther
- Tscheliessnigg Karlheinz
- Wasler Andrae
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- Dimensions Citations:
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- Abstract:
- Besides the current classification of cytomegalovirus (CMV) infection and disease we defined "CMV antigenaemia" as the marker for initiation of antiviral therapy (CMV hyperimmune globulin 2 ml/kg/d and ganciclovir 1000 mg/d), and "episodes of CMV antigenaemia"(the time from detection of antigenaemia until a subsequent antigenaemia assay tested negative again) indicated the time period of antiviral treatment. Patients were at highest risk for antigenaemia at day 38.2 +/- 20.9 after heart transplantation. We observed 50 episodes of antigenaemia in 18 patients. The mean duration was 7.3 +/- 6.4 days. No antigenaemia associated symptoms and no anti-CMV IgM was observed without preceding evidence of antigenaemia. Antigenaemia-associated symptoms and antigenaemia disappeared after antiviral therapy was initiated. Our therapy did not prevent CMV infection, but despite the repeated evidence of active CMV infection, no patient suffered CMV disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Antigens, Viral - blood
- Antiviral Agents - therapeutic use
- Biomarkers - blood
- Cytomegalovirus - isolation & purification
- Cytomegalovirus Infections - diagnosis
- Cytomegalovirus Infections - drug therapy
- Cytomegalovirus Infections - etiology
- Cytomegalovirus Infections - prevention & control
- Enzyme-Linked Immunosorbent Assay -
- Ganciclovir - therapeutic use
- Heart Transplantation - adverse effects
- Heart Transplantation - immunology
- Humans -
- Immunoglobulin G - blood
- Immunoglobulin M - blood
- Immunoglobulins, Intravenous - therapeutic use
- Postoperative Complications - prevention & control
- Prospective Studies -
- Transplantation Immunology -
- Viremia - immunology