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Selected Publication:
Smolle-Jüttner, FM; Popper, H; Klemen, H; Pinter, H; Pongratz-Roeger, M; Smolle, J; Friehs, G.
Clinical features and therapy of typical and atypical bronchial carcinoid tumors (grade 1 and grade 2 neuroendocrine carcinoma).
Eur J Cardiothorac Surg. 1993; 7(3):121-124
Doi: 10.1016/1010-7940(93)90033-8
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PubMed
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- Leading authors Med Uni Graz
- Smolle-Juettner Freyja-Maria
- Co-authors Med Uni Graz
- Klemen Huberta
- Pinter Hans
- Popper Helmuth
- Smolle Josef
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- Abstract:
- Between 1971 and 1992, 55 patients with grade 1 (G1) (n = 32) or grade 2 (G2) (n = 23) neuroendocrine bronchial carcinomas (males: 26, females: 29; mean age: 47.7 years, range: 13-77 years) were treated. The sexes were evenly distributed in the two groups. Patients with G1 were significantly younger than those with G2 tumors (43.3 vs 53.7 years; P < 0.05). There were no statistically significant differences between G1 and G2 concerning peripheral or central localization, laterality or maximum tumor diameters. Patients with G1 had a higher incidence of tumor-related symptoms and a longer mean duration of these symptoms (21.8 months) than G2 cases (14 months) but the differences were not statistically significant either. No case displayed any symptoms of hormonal activity. Fifty-two patients underwent resection, one was non-resectable for anatomical, and one for functional, reasons; a third refused an operation. We performed 8 pneumonectomies, 36 lobectomies (8 by using bronchoplasty), 2 bronchotomies and 6 segmental resections. Twelve G2 cases had N1 or N2 lymph node metastases, two intrapulmonary metastases were removed. After a median observation time of 55.7 months the 10-year survival rate for the total collective is 90.6%. For G1 it is 100%, compared with 76.4% for G2 patients, 3 of whom died of the tumor (P < 0.05; significant). In univariate analysis: age over 48 years, lymphatic invasion, and lymph node metastasis were also significantly correlated with a poor survival rate. Multivariate analysis proved lymphatic permeation to be the only independent prognostic factor (the survival rate was 100% where there was no invasion, but only 74% where this had occurred).
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Analysis of Variance -
- Carcinoma, Adenoid Cystic - mortality
- Carcinoma, Bronchogenic - classification
- Chi-Square Distribution - classification
- Cohort Studies - classification
- Female - classification
- Humans - classification
- Lung Neoplasms - mortality
- Lymphatic Metastasis - mortality
- Male - mortality
- Middle Aged - mortality
- Multivariate Analysis - mortality
- Neoplasm Staging - mortality
- Prognosis - mortality
- Survival Rate - mortality
- Find related publications in this database (Keywords)
- NEUROENDOCRINE CARCINOMA
- CARCINOID
- BRONCHUS
- CLINICAL FINDINGS