Medizinische Universität Graz - Research portal
Selected Publication:
Sill, H; Rule, SA; Joske, DJ; Chase, A; Lin, F; Goldman, JM; Cross, NC.
Reconstitution with Philadelphia chromosome-negative recipient haematopoiesis early after allogeneic BMT for CML.
Bone Marrow Transplant. 1996; 17(3):453-455
(- Case Report)
Web of Science
PubMed
- Leading authors Med Uni Graz
- Sill Heinz
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- Abstract:
- We report a 33-year-old man with Ph chromosome-positive CML who underwent an allogeneic BMT from an unrelated donor. DNA microsatellite studies showed complete donor chimaerism immediately after BMT followed by mixed chimaerism; by day + 45 haematopoiesis was exclusively of recipient origin. Throughout the first year post-transplant all marrow metaphases were Ph negative but with non-clonal rearrangements consistent with autologous recovery. Cytogenetic relapse of leukaemia was first detected 15 months post-transplant. This case is unusual in that non-malignant stem cells of recipient origin survived the transplant and reconstituted haematopoiesis very early after BMT. Later the leukaemic cells reasserted their 'proliferative' advantage.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Bone Marrow Transplantation -
- Hematopoiesis - physiology
- Humans - physiology
- Leukemia, Myeloid, Chronic - genetics
- Leukemia, Myeloid, Philadelphia-Negative - genetics
- Leukemia, Myeloid, Philadelphia-Positive - genetics
- Male - genetics
- Recurrence - genetics
- Transplantation, Homologous - genetics
- Find related publications in this database (Keywords)
- mixed chimaerism
- host haematopoiesis
- CML
- Ph-negative