Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Smolle-Juettner, FM; Mayer, R; Pinter, H; Stuecklschweiger, G; Kapp, KS; Gabor, S; Ratzenhofer, B; Hackl, A; Friehs, G.
"Adjuvant" external radiation of the mediastinum in radically resected non-small cell lung cancer.
Eur J Cardiothorac Surg. 1996; 10(11):947-950
Doi: 10.1016/s1010-7940(96)80395-2
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- Führende Autor*innen der Med Uni Graz
- Smolle-Juettner Freyja-Maria
- Co-Autor*innen der Med Uni Graz
- Gabor Sabine
- Kapp Karin S.
- Mayer Ramona
- Ratzenhofer-Komenda Beatrice
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- Abstract:
- The effect of postoperative external beam radiation in MO non-small cell lung cancer resected with curative intention was evaluated in a randomized trial. In 155 patients (121 males, 34 females; mean age: 59 years) 105 lobectomies, 12 bilobectomies and 38 pneumonectomies with radical lymph node dissection to the contralateral side were carried out. Histology revealed squamous cell (n = 68), adeno- (n = 53), large cell (n = 21), adenosquamous (n = 6) or bronchioloalveolar type (n = 7) carcinomas. The pathologic stages T1 (n = 38), T2 (n = 89), T3 (n = 28); NO (n = 39), N1 (n = 67), and N2 (n = 49) were evenly distributed between the two treatment groups: group A (72 patients) had no further oncologic treatment, while group B (83 patients) had external beam radiation to the mediastinum (50-56 Gy, 8 or 23 MeV photons, 2 Gy/day, 5 days a week) beginning 4 weeks after the operation. The overall 5-year survival rate of the whole collective was 24.1% without any significant difference between the radiotherapy group B (29.7%) and the control group A (20.4%) (log-rank test: P > 0.05). The overall 5-year recurrence-free survival rate was 20.1%, with no difference between groups B and A (radiotherapy: 22.7, controls: 15.6%, long-rank test: P > 0.05). There was no difference in the incidence of distant metastases (external beam radiation: n = 32; controls: n = 38). The rate of local recurrences at the bronchial stump or in the mediastinum, however, was significantly reduced in the radiotherapy group (n = 5) compared with 17 in the controls (P < 0.01 chi-square test). A multivariate analysis confirmed the independent influence of postoperative radiotherapy on the incidence of local recurrence. External radiation of the mediastinum in radically resected non-small cell lung cancer reduces the risk of local recurrence, but has no influence on distant metastastic spread and overall survival.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma, Bronchiolo-Alveolar - pathology
- Adult -
- Aged -
- Carcinoma, Adenosquamous - pathology
- Carcinoma, Non-Small-Cell Lung - mortality
- Carcinoma, Non-Small-Cell Lung - therapy
- Carcinoma, Squamous Cell - pathology
- Combined Modality Therapy -
- Disease-Free Survival -
- Female -
- Follow-Up Studies -
- Humans -
- Lung Neoplasms - mortality
- Lung Neoplasms - pathology
- Lung Neoplasms - therapy
- Lymph Node Excision -
- Male -
- Mediastinum - radiation effects
- Middle Aged -
- Multivariate Analysis -
- Neoplasm Metastasis -
- Neoplasm Recurrence, Local -
- Pneumonectomy -
- Radiotherapy, Adjuvant -
- Survival Rate -
- Find related publications in this database (Keywords)
- lung cancer
- surgery
- postoperative radiotherapy
- survival
- recurrence