Medizinische Universität Graz - Research portal
Selected Publication:
Fink-Puches, R; Helige, C; Kerl, H; Smolle, J; Tritthart, HA.
Inhibition of melanoma cell directional migration in vitro via different cellular targets.
Exp Dermatol. 1993; 2(1):17-24
Doi: 10.1111/j.1600-0625.1993.tb00194.x
PubMed
FullText
FullText_MUG
Google Scholar
- Leading authors Med Uni Graz
- Fink-Puches Regina
- Co-authors Med Uni Graz
- Helige Christine
- Kerl Helmut
- Smolle Josef
- Tritthart Helmut
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- In malignant melanoma active movement of cancer cells is considered to be essential for tissue invasion. Various mechanisms, such as the Ca(2+)-calmodulin-proteinkinase C cascade or G-protein-dependent processes are considered to play a role in tumor cell functions. The assay of directional migration, combined with computer-assisted image analysis, was used to evaluate the antimigratory efficacy of drugs interfering with different steps of signal transduction pathways. Treatment with different compounds showed a more or less concentration-dependent reduction of migration rates: The Ca(2+)-channel blockers verapamil and devapamil showed a slight reduction of motility. The effect was more pronounced when the calmodulin antagonist flunarizine was used or the proteinkinase C inhibitors dequalinium, tamoxifen and H-7 were applied. A marked inhibition of motility was found with the G-protein antagonist L 651582. Thus, our results indicate that different signal transduction pathways are involved in the regulation of directional migration of K1735-M2 melanoma cells.
- Find related publications in this database (using NLM MeSH Indexing)
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine -
- Aminoimidazole Carboxamide - analogs and derivatives
- Animals - analogs and derivatives
- Calcium Channel Blockers - pharmacology
- Cell Division - drug effects
- Cell Movement - drug effects
- Dequalinium - pharmacology
- Flunarizine - pharmacology
- GTP-Binding Proteins - antagonists and inhibitors
- Isoquinolines - pharmacology
- Melanoma, Experimental - pathology
- Mice - pathology
- Piperazines - pharmacology
- Protein Kinase C - antagonists and inhibitors
- Signal Transduction - drug effects
- Tamoxifen - pharmacology
- Triazoles - pharmacology
- Tumor Cells, Cultured - drug effects
- Verapamil - analogs and derivatives