Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fridrik, MA; Hausmaninger, H; Linkesch, W; Stöger, M; Sill, H; Neubauer, M; Seewann, HL; Klocker, J; Haidinger, R; Schiller, L; Pont, J; Raudaschl, G; Falk, M; Radaszkiewicz, T.
CEOP-IMVP-Dexa in the treatment of aggressive lymphomas: an Austrian multicenter trial.
J CLIN ONCOL. 1996; 14(1): 227-232.
Doi: 10.1200/JCO.1996.14.1.227
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- Co-Autor*innen der Med Uni Graz
- Linkesch Werner
- Sill Heinz
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- Abstract:
- PURPOSE: This trial evaluated the efficacy, toxicity, and practicability of a new intensive chemotherapy regimen in a multicenter setting of university and community hospitals. PATIENTS AND METHODS: We tested a hybrid protocol of two non-cross-resistant regimens, cyclophosphamide, epirubicin, vincristine, and prednisolone (CEOP) and ifosfamide, etoposide (VP-16), methotrexate, and dexamethasone (IMVP-Dexa) given every fourth week, three to six times according to response, in patients with untreated intermediate- and high-grade non-Hodgkin's lymphoma. Ten Austrian centers entered 81 patients onto this multicenter trial. Eleven patients were excluded. The median age was 55 years. Twenty-six of 70 patients had stage III or IV disease. The distribution among international risk categories low, intermediate-low, intermediate-high, and high was 20%, 34%, 23%, and 23%, respectively. RESULTS: Of 70 eligible patients, 56 (80%) had a complete remission and seven (10%) a partial remission. After a median observation time of 36 months, the estimated time to relapse and overall survival rates are 67% and 72%, respectively. Age and Karnofsky index were the only independent risk factors for survival. Toxicity was primarily hematologic, with a median granulocyte nadir of 0.56 x 10(9)/L. Sixty-seven percent of patients had infections; 25.7% were severe World Health Organization (WHO) grade III or IV. There were three treatment-related deaths. CONCLUSION: CEOP-IMVP-Dexa chemotherapy is safe and feasible on a groupwide basis even when used in community hospitals. Neutropenic infections are the major complications. A 72% 3-year survival rate in patients with intermediate- and high-grade non-Hodgkin's lymphoma warrants further studies. These data are the basis for a randomized trial to compare cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) with CEOP/IMVP-Dexa.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Antineoplastic Combined Chemotherapy Protocols - adverse effects
- Cyclophosphamide - administration and dosage
- Dexamethasone - administration and dosage
- Epirubicin - administration and dosage
- Etoposide - administration and dosage
- Feasibility Studies - administration and dosage
- Female - administration and dosage
- Folic Acid - administration and dosage
- Hematologic Diseases - chemically induced
- Humans - chemically induced
- Ifosfamide - administration and dosage
- Karnofsky Performance Status - administration and dosage
- Lymphoma, High-Grade - drug therapy
- Lymphoma, Intermediate-Grade - drug therapy
- Male - drug therapy
- Mesna - administration and dosage
- Methotrexate - administration and dosage
- Middle Aged - administration and dosage
- Multivariate Analysis - administration and dosage
- Neoplasm Staging - administration and dosage
- Prednisolone - administration and dosage
- Remission Induction - administration and dosage
- Risk Factors - administration and dosage
- Survival Rate - administration and dosage
- Vincristine - administration and dosage