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Braunschweig, F; Fahrleitner-Pammer, A; Mangiavacchi, M; Ghio, S; Fotuhi, P; Hoppe, UC; Linde, C.
Correlation between serial measurements of N-terminal pro brain natriuretic peptide and ambulatory cardiac filling pressures in outpatients with chronic heart failure.
Eur J Heart Fail. 2006; 8(8): 797-803.
Doi: 10.1016/j.ejheart.2006.03.002
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- Co-authors Med Uni Graz
- Fahrleitner-Pammer Astrid
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- Abstract:
- BACKGROUND: Serial measurements of N-terminal pro brain natriuretic peptide (NT-proBNP) have been suggested for the management of outpatients with chronic heart failure (CHF). The relationship between NT-proBNP plasma levels and central haemodynamic parameters in this setting is not known. METHODS: In 19 outpatients with CHF, NT-proBNP was related to central haemodynamic information, continuously measured with an implanted haemodynamic monitor (IHM) during 24 h of daily living activities ("24 h") and during supine rest ("rest"). In 13 patients, three to seven serial measurements were obtained with a mean time interval of 39 days (range 19-113). RESULTS: At the first visit (n=19), NT-proBNP plasma levels were dispersed over a wide range of filling pressures and not correlated with the 24 h median of the right ventricular systolic pressure (RVSP) and the estimated pulmonary artery pressure (ePAD). However, in the individual patient, serial measurements yielded significant positive correlations between NT-proBNP and RVSP (p=0.006) and ePAD (p=0.001). During "24 h" compared with "rest", the median RVSP and ePAD were elevated by 20+/-16% and 32+/-18%, respectively, and corresponded better with NT-proBNP (p<0.05). CONCLUSION: In outpatients with CHF, single measurements of NT-proBNP are not correlated with cardiac filling pressures. However, serial measurements of NT-proBNP in each individual patient show a significant positive correlation with central haemodynamic parameters and reflect changes in the haemodynamic state over time.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Blood Pressure -
- Female -
- Heart Failure - blood
- Humans - blood
- Male - blood
- Middle Aged - blood
- Natriuretic Peptide, Brain - blood
- Outpatients - blood
- Peptide Fragments - blood
- Time Factors - blood
- Find related publications in this database (Keywords)
- natriuretic peptides
- chronic heart failure
- haemodynamics
- implantable devices