Medizinische Universität Graz - Research portal
Selected Publication:
Smolle, J; Hofmann-Wellenhof, R; Fink-Puches, R.
Melanoma and stroma: an interaction of biological and prognostic importance.
SEMIN CUTAN MED SURG. 1996; 15(4): 326-335.
Doi: 10.1016/S1085-5629(96)80046-0
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Leading authors Med Uni Graz
- Smolle Josef
- Co-authors Med Uni Graz
- Fink-Puches Regina
- Hofmann-Wellenhof Rainer
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Stromal relationships are crucial to metastatic spread of solid malignancies. Some aspects of this stroma interaction are obviously associated with particular morphological features, which may carry prognostic significance. In cutaneous melanoma, level of invasion, arrangement of cells (horizontal or vertical growth phase), neovascularization, vessel invasion, architecture of the border, and inflammatory infiltrate have been examined. Expression of adhesion molecules, signalling factors, cytoskeletal components, extracellular matrix molecules and matrix-degrading enzymes have been assessed by immunohistology and in situ hybridization. Besides providing prognostic information, a thorough evaluation of stromal relationships may help to increase our knowledge about factors mediating the growth and metastatic spread of malignancies.
- Find related publications in this database (using NLM MeSH Indexing)
- Disease Progression -
- Humans -
- Melanoma - diagnosis
- Neoplasm Invasiveness - pathology
- Neoplasm Metastasis - pathology
- Prognosis - pathology
- Skin - cytology
- Skin Neoplasms - diagnosis
- Stromal Cells - pathology