Medizinische Universität Graz - Research portal
Selected Publication:
März, W; Scharnagl, H; Abletshauser, C; Hoffmann, MM; Berg, A; Keul, J; Wieland, H; Baumstark, MW.
Fluvastatin lowers atherogenic dense low-density lipoproteins in postmenopausal women with the atherogenic lipoprotein phenotype.
CIRCULATION 2001 103: 1942-1948.
Doi: 10.1161/01.CIR.103.15.1942
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- Leading authors Med Uni Graz
- März Winfried
- Co-authors Med Uni Graz
- Scharnagl Hubert
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- Abstract:
- BACKGROUND: Although HMG-CoA reductase inhibitors (HMGRIs) are effective lipid-lowering agents, it remains controversial whether these agents also lower dense LDL (dLDL), a predominance of which is considered to contribute to the atherogenicity of the metabolic syndrome. METHODS AND RESULTS: In a multicenter, double-blind, randomized, placebo-controlled study, we determined the effect of the HMGRI fluvastatin on lipids, apolipoproteins, and LDL subfractions (by equilibrium density gradient ultracentrifugation). A total of 52 postmenopausal women with combined hyperlipidemia and increased dLDL were treated with either fluvastatin 40 mg/d (n=35) or placebo (n=17). After 12 weeks' treatment, significant reductions (P<0.001) in total cholesterol (-19%), IDL cholesterol (-35%), LDL cholesterol (-23%), apolipoprotein B (-21%), and apolipoprotein B in dLDL (-42%) were apparent among fluvastatin recipients. No significant changes in triglycerides or HDL cholesterol were observed. The effect of fluvastatin on dLDL was correlated with baseline values. There was no consistent relationship, however, between the effect of fluvastatin on triglycerides and the decrease in dLDL. CONCLUSIONS: Fluvastatin lowers total and LDL cholesterol and the concentration of dLDL. This profile may contribute to an antiatherogenic effect for fluvastatin that is greater than expected on the basis of changes in lipids and apolipoproteins.
- Find related publications in this database (using NLM MeSH Indexing)
- Anticholesteremic Agents - administration and dosage
- Apolipoproteins B - blood
- Cholesterol - blood
- Double-Blind Method - blood
- Fatty Acids, Monounsaturated - administration and dosage
- Female - administration and dosage
- Humans - administration and dosage
- Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration and dosage
- Hyperlipidemia - blood
- Indoles - administration and dosage
- Lipoproteins - blood
- Lipoproteins, HDL Cholesterol - blood
- Lipoproteins, LDL - blood
- Lipoproteins, LDL Cholesterol - blood
- Phenotype - blood
- Postmenopause - blood
- Research Support, Non-U.S. Gov't - blood
- Treatment Outcome - blood
- Triglycerides - blood
- Find related publications in this database (Keywords)
- fluvastatin
- coronary disease
- lipoproteins